Acquired haemophilia is a rare autoimmune condition with an annual incidence of one per million. It is more common in the elderly and is associated with the presence of anti-factor VIII IgG antibodies. Most cases are idiopathic but there are also known associations with malignancy, other autoimmune diseases and drug interactions. As aging itself is not a cause of changes...
(Vol 15 p 4-6, Emergency Medicine and Surgery; Haematology: 14 May 2015)
Multiple pathologic fractures in a patient with sickle cell disease is rare; bone involvement is well documented in this disease, however multiple pathologic fractures as a complication are uncommon. We present a case involving a 19-month-old boy known to have sickle cell disease who developed multiple pathologic fractures as a complication of his disease. The patient was...
(Vol 13 p 63-68, Haematology; Orthopaedics; Paediatrics; Pathology; Radiology: 22 July 2013)
A 4-year-old boy with beta-thalassemia major who underwent a successful bone marrow transplant (BMT), presented with a necrotic looking scalp lesion. Debridement was initially suggested but a punch biopsy showed Aspergillus fumigatus. Antifungal therapy was commenced and the lesion healed with minimal scarring. Invasive fungal infections are a major cause of morbidity and...
(Vol 11 p 66-69, Dermatology; Haematology; Paediatric Surgery: 12 August 2011)
Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary...
(Vol 11 p 56-59, Haematology; Histopathology; Nephrology; Neurology; Pathology; Radiology: 18 July 2011)
We describe a case of very late stent thrombosis (ST) in a patient presenting with hematemesis while taking aspirin and oral anticoagulation therapy (OAC). This case shows that the management of patients with an indication for OAC who undergo percutaneous coronary intervention with drug-eluting stent (DES) implantation is challenging because of the need to balance the...
(Vol 11 p 48-52, Cardiology; Emergency Medicine; Gastroenterology; Haematology; Histopathology; Pathology: 18 July 2011)
Pure red cell aplasia (PRCA) is a rare complication of autoimmune rheumatic diseases such as systemic lupus erythematosus (SLE). Thymoma occurs in 5–13% of patients with PRCA and in 2% of patients with SLE. The simultaneous occurrence, however, of all 3 disorders is rare. We report a patient with lupus-like disease who developed PRCA in association with a...
(Vol 11 p 37-40, Haematology; Rheumatology: 14 June 2011)
Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII inhibitor and lupus anticoagulant. Clinical findings included large hemorrhagic areas of the extremities, a prolonged activated partial thrombin time (aPTT) that...
(Vol 10 p 19-24, Haematology; Oncology: 6 April 2010)


Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK


Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

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