Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary...
(Vol 11 p 56-59, Haematology; Histopathology; Nephrology; Neurology; Pathology; Radiology: 18 July 2011)
Neuromyelitis optica (NMO) and systemic inflammatory diseases are not mutually exclusive. Even when other autoantibodies are present, myelitis extending over 3 vertebral segments with NMO-IgG positivity discloses the diagnosis of NMO. We report the case of an isolated myelitis extending over 6 vertebral segments due to neuromyelitis optica (NMO). Despite the absence of...
(Vol 10 p 103-106, Neurology; Rheumatology: 1 December 2010)
A 73-year-old lady became bed bound with progressive generalized weakness 2 weeks after the introduction of sodium fusidate for osteomyelitis. She was already on simvastatin for years. Electromyography showed no spontaneous muscle activity from any of the muscles sampled. The temporal relationship of symptom onset after introduction of fusidic acid and full recovery after...
(Vol 10 p 82-85, Neurology: 22 October 2010)
We present a case of a 59-year-old gentleman with myasthenia gravis and metastatic renal cell carcinoma that resolved on sunitinib. The clear temporal relationship between the patient receiving sunitinib for renal cell carcinoma and the resolution of his myasthenia gravis suggests that the improvement was due either to a paraneoplastic condition responding to treatment of...
(Vol 10 p 42-45, Neurology; Oncology; Urology: 22 July 2010)
A case of Epstein–Barr virus (EBV) meningoencephalitis in a 74-year-old white man with rheumatoid arthritis is reported. The potential predisposing factors for EBV meningoencephalitis, the diagnostic approach and the management highlighted by this case are discussed.
(Vol 9 p 49-53, Infection and immunity; Neurology; Rheumatology: 31 December 2009)
A 60-year-old woman attended A&E following an unwitnessed ‘collapse query cause’. Over 4 months she recalled involuntary movement of her eyes and head to the left and, on one occasion, complete rotation of her body. She had subtle neurological signs. Imaging identified the cause of these adversive seizures.
(Vol 7 p 61-63, Accident and Emergency Medicine and Surgery (including Trauma); Neurology; Neuroradiology; Neurosurgery: 13 June 2007)
VKH disease is an idiopathic chronic granulomatous inflammatory disorder. It has ophthalmic, neurological and cutaneous manifestations. The clinical picture is variable and dependent on the stage of presentation. We report on a patient who presented with a mixed picture of early and late onset symptoms with clinical findings of acute on chronic inflammation.
(Vol 6 p 4-7, Ophthalmology, Neurology: 1 May 2006)
Electrical brain responses to words semantically related versus unrelated to their context were recorded in a coma patient on days 6 (Glasgow Coma Scale, GCS=6) and 22 (GCS=9). Significant differences between related and unrelated words (which were completely matched in their physical features) were consistently observed in both examinations. This is the first evidence...
(Vol 5 p 37-41, Neurology, Medical psychology, Critical care: September 2005)
A number of paraneoplastic neurological syndromes have been described in association with small cell lung carcinoma and, less commonly, with other malignancies. We describe here the case of a 58-year-old woman with paraneoplastic limbic encephalitis (PLE) complicating squamous cell carcinoma of the lung.She presented with subacute cognitive decline, particularly memory...
(Vol 2 p 46-49, Neurology, Oncology: August 2002)
An ironic poem written at the time of a transient ischaemic attack is illustrated which demonstrates the expressive nature of dysphasic dysgraphia at the moment of the attack (Fig. 1).
(Vol 2 p 35-36, Neurology: July 2002)


Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK


Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

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